Eye-Volution™ with Elustra™ (d9-Caffeine) Demonstrates Clinically Proven Results in Anti-Aging Eye Serum Study

D9 Designs Announces Clinical Results for Eye-Volution™ Featuring Elustra™

May 12, 2025

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D9 Designs Inc., a science-forward company and the creators of Elustra™ (patent-pending d9-Caffeine for topical use), has announced the successful completion of two independent third-party clinical studies for Eye-Volution™, its flagship multi-action eye serum.

The results confirm what Elustra™ (d9-Caffeine) was designed to deliver: measurable, multi-dimensional performance around the eyes — all while remaining gentle enough for daily use.

Clinically Proven Results at 4 and 8 Weeks

In an 8-week efficacy study conducted by an independent dermatology research lab, Eye-Volution™ delivered statistically significant improvements across five key skin health markers:

• Hydration: 94% of participants experienced a measurable increase in skin hydration.
• Barrier Function: Over 70% showed improved skin barrier integrity (via TEWL).
• Firmness & Elasticity: Over 77% of participants showed measurable improvement in elasticity by Week 4, while firmness benefits were sustained through Week 8.‍
• Fine Lines & Wrinkles: 77% saw visible improvements in the appearance of fine lines and wrinkles around the eye area by Week 8.‍
• Overall Satisfaction: 95% of subjects reported being satisfied with the results after 8 weeks of use.

All improvements were supported by instrumental measurement (corneometer, tewameter, cutometer) and dermatological expert grading.

Safety Backed by HRIPT Testing

A separate 52-person Human Repeat Insult Patch Test (HRIPT) confirmed the safety profile of Eye-Volution™, showing no irritation, no sensitization, and no adverse events. The study supports the following substantiated claims:

• Dermatologist-Tested
• Clinically Tested
• Non-Irritating
• Non-Sensitizing

Both studies were conducted in compliance with International Council on Harmonization Good Clinical Practice (ICH GCP) and applicable U.S. regulations.

Powered by Elustra™

Eye-Volution™ is the first product to feature Elustra™, D9 Designs’ proprietary form of deuterated caffeine designed specifically for topical application. Unlike traditional caffeine, Elustra™ is engineered for enhanced stability and bioavailability, supporting both immediate and long-term benefits in skin hydration, circulation, and barrier repair.

“Hydration, firmness, and wrinkle reduction were all validated using gold-standard dermatologic instruments in an independent 8-week study under clinical oversight. At the core is Elustra™, our patent-pending form of topical d9-Caffeine, which works synergistically with a powerful blend of actives to deliver real, measurable skin transformation,” said Dr. Bruce Lavin, MD, MPH, CSO and Co-Founder of d9 Designs Inc.

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Introducing Derma9™: A New Era of Elustra™- Powered Skincare

Eye-Volution™ marks the debut product in the Derma9™ skincare line—a science-forward brand committed to developing targeted treatments powered by Elustra™, D9 Designs’ proprietary form of d9-Caffeine. Additional formulations are already in development, each designed to maximize the long-term performance benefits of this breakthrough molecule.

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For full study reports or more information , visit https://www.d9designs.com/studies/elustra.